Fisiologi Mukosiliar Bronkus

Main Article Content

Harry Pasca Rullian
Fakultas Kedokteran Universitas Andalas
Masrul Basyar
Fakultas Kedokteran Universitas Andalas
Dewi Wahyu Fitrina
Fakultas Kedokteran Universitas Andalas

One of the defense systems possessed by the respiratory tract is mucociliary transport. In order for this system to work properly, coordination of 3 components is required, namely: the motile cila, the periciliar layer (PCL), and the mucus layer. The mucus layer will catch foreign particles that enter the respiratory tract. The motile cilia will push the mucus to keep moving towards the proximal airway until it finally reaches the oropharynx and is swallowed. Cilia movement is certainly influenced by PCL which is a medium for cilia to move. In some lung diseases, this component can be impaired so that the mucociliary transport process does not work effectively.

Keywords: Mucociliar, Mucociliar Transport, Cilia, Mucus, Periciliar Layer
Benhans, Devina, Ningsih, Vivian Febri, Jong, Ricky, Febrianto, Febrianto, Evander, Owen, Wijaya, Gautama, & Aripradono, Heru Wijayanto. (2023). Deteksi Gangguan Kesehatan Melalui Analisis Suara: Pendeteksian Gejala Pernapasan Abnormal dan Suara Jantung tidak sehat menggunakan Kecerdasan Buatan. Journal of Information System and Technology (JOINT), 4(3), 435–438.
Cai, Liheng. (2012). Structure and function of airway surface layer of the human lungs & mobility of probe particles in complex fluids. The University of North Carolina at Chapel Hill.
Chung, Kian Fan, & Pavord, Ian D. (2008). Prevalence, pathogenesis, and causes of chronic cough. The Lancet, 371(9621), 1364–1374.
Clunes, Mark T., & Boucher, Richard C. (2008). Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis. Current Opinion in Pharmacology, 8(3), 292–299.
Fahy, John V, & Dickey, Burton F. (2010). Airway mucus function and dysfunction. New England Journal of Medicine, 363(23), 2233–2247.
Farkas, Árpád, & Szöke, István. (2013). Simulation of bronchial mucociliary clearance of insoluble particles by computational fluid and particle dynamics methods. Inhalation Toxicology, 25(10), 593–605.
Frida, N. (2020). Penyakit Paru-Paru dan Pernapasan. Alprin.
Horsfield, Keith, & Cumming, Gordon. (1968). Morphology of the bronchial tree in man. Journal of Applied Physiology, 24(3), 373–383.
Klingele, TERENCE G., & Staub, NORMAN C. (1971). Terminal bronchiole diameter changes with volume in isolated, air-filled lobes of cat lung. Journal of Applied Physiology, 30(2), 224–227.
Mar’iyah, Khusnul, & Zulkarnain, Zulkarnain. (2021). Patofisiologi penyakit infeksi tuberkulosis. Prosiding Seminar Nasional Biologi, 7(1), 88–92.
Moniaux, Nicolas, Escande, Fabienne, Porchet, Nicole, Aubert, Jean Pierre, & Batra, Surinder K. (2001). Structural organization and classification of the human mucin genes. Front Biosci, 6(1), D1192–D1206.
Munkholm, Mathias, & Mortensen, Jann. (2014). Mucociliary clearance: pathophysiological aspects. Clinical Physiology and Functional Imaging, 34(3), 171–177.
Noone, Peadar G., Leigh, Margaret W., Sannuti, Aruna, Minnix, Susan L., Carson, Johnny L., Hazucha, Milan, Zariwala, Maimoona A., & Knowles, Michael R. (2004). Primary ciliary dyskinesia: diagnostic and phenotypic features. American Journal of Respiratory and Critical Care Medicine, 169(4), 459–467.
Proud, David. (2008). The pulmonary epithelium in health and disease.
van der Schans, Cees P. (2007). Bronchial mucus transport. Respiratory Care, 52(9), 1150–1158.